Showing experiments where 3,4-Dihydroxyphenylacetic acid has been detected in biofluids Metabolism
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| [polyphenol] source used in experiment | Source composition | Doses administered | Dose duration | Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| human studies | ||||||||||||
| 5-caffeoylquinic acid | Not applicable | 2 g/day | 7 days | 20 | 24 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| almond skin extract capsules |
Food administered |
10 capsules | Single dose | 2 | URPI-SARDA 2009_02 | |||||||
| black tea solids |
Food administered |
4 g/day | 7 days | 20 | 26 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| citric acid in water | Not applicable | 0.5 g/day | 7 days | 20 | 19 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| cocoa powder in skimmed milk |
Food administered Generic food |
40 g/day | 4 weeks | 42 | 1.44 µmol after 24 hours | 0.11 µmol/L after 24 hours | URPI-SARDA 2009_03 | |||||
| cocoa powder in water |
Food administered Generic food |
40 g | Single dose | 21 |
|
URPI-SARDA 2010 | ||||||
| cocoa powder in whole milk |
Food administered Generic food |
40 g | Single dose | 21 |
|
URPI-SARDA 2010 | ||||||
| dark chocolate | Generic food | 80 g | Single dose | 11 |
|
RIOS 2003 | ||||||
| quercetin 3-O-rutinoside | Not applicable | 440 mg/day | 7 days | 20 | 52 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| rat studies | ||||||||||||
| 5-caffeoylquinic acid | Not applicable | 250 µmol/day | 8 days | 8 | 0.28 µmol after 8 days | GONTHIER 2003_01 | ||||||
| caffeic acid | Not applicable | 250 µmol/day | 8 days | 8 | 0.28 µmol after 8 days | GONTHIER 2003_01 | ||||||
| catechin | Not applicable | 0.12 g/100 g bw | Single dose | 8 | 100.8 µg after 8 days | GONTHIER 2003_03 | ||||||
| catechin | Not applicable | 0.1 % of diet | 5 days | 5 | 0.25 µmol after 5 days | GONTHIER 2003_02 | ||||||
| cranberry powder diet |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 1.32 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| natural cocoa |
Food administered |
10 % of diet | 2 weeks | 7 | 0.4 nmol/mg creatinine after 14 days | URPI-SARDA 2009_01 | ||||||
| natural cocoa powder |
Food administered |
4.8 g/kg bw/day | 2 weeks | 7 | 0.94 nmol/mg creatinine after 14 days | URPI-SARDA 2009_01 | ||||||
| procyanidin dimer B3 | Not applicable | 0.1 % of diet | 5 days | 5 | 0.65 µmol after 5 days | GONTHIER 2003_02 | ||||||
| procyanidin polymers | Not applicable | 0.1 % of diet | 5 days | 5 | 2.25 µmol after 5 days | GONTHIER 2003_02 | ||||||
| procyanidin trimer C2 | Not applicable | 0.1 % of diet | 5 days | 5 | 0.2 µmol after 5 days | GONTHIER 2003_02 | ||||||
| quinic acid | Not applicable | 250 µmol/day | 8 days | 8 | 0.48 µmol after 8 days | GONTHIER 2003_01 | ||||||
| wine powder |
Food administered |
0.5 g/100 g bw | Single dose | 8 | 104 µg after 8 days | GONTHIER 2003_03 | ||||||
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| [polyphenol] source used in experiment | Source composition | Doses administered | Dose duration | Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| human studies | ||||||||||||
| tomato juice enriched with rutin |
Food administered |
300 mL | Single dose | 6 |
|
JAGANATH 2006 | ||||||
| rat studies | ||||||||||||
| cranberry powder diet |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 0.72 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||